Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle
نویسندگان
چکیده
A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.
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INTRODUCTION Although fracture healing often occurs without complications, a significant proportion (5 to 10 %) of fractures fail to heal and result in delayed union or persistent nonunion [1]. To enhance the fracture healing, a variety of treatment techniques have been developed. Bone morphogenetic protein-7 (BMP-7) has been reported to promote bone formation in nonunions [2]. It is also well-...
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